Hypotheses and Dynamics in the Pathogenesis of Neurodegenerative Disorders

Indexed in: Scopus, EBSCO.

This book presents a series of clinical and pathologic observations that are thought to contribute to progressive incremental severity in neuronal cell loss and tissue atrophy in the cerebral cortex. ...
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DIMENSIONS OF GLOBAL BRAIN INVOLVEMENT

Pp. 47-56 (10)

Lawrence M. Agius

Abstract

Relative attempts at modulation and manipulative processing of neurotransmitter release and receptivity at the post-synaptic membrane appear central to the consequences of synaptic loss in Alzheimer’s disease. In view of the ongoing dynamics of further injury to neurons in this disorder, it would perhaps prove important to recognize consequences of disease as themselves pathogenic targets in the evolutionary definition of further injury as progression, particularly in terms of both neuronal cell and synapse loss.

Affiliation:

University of Malta Medical School Mater Dei Hospital, Malta