Hypotheses and Dynamics in the Pathogenesis of Neurodegenerative Disorders

Indexed in: Scopus, EBSCO.

This book presents a series of clinical and pathologic observations that are thought to contribute to progressive incremental severity in neuronal cell loss and tissue atrophy in the cerebral cortex. ...
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DEFINING PARAMETERS OF NEURODEGENERATION

Pp. 13-19 (7)

Lawrence M. Agius

Abstract

The various dimensional attributes of an actively progressive neurodegenerative process closely resembles the evolutionary dynamics of a predetermined cascade that is defined as pathway endresult. It is significant to view the different contrasting processes as events individually evolving in terms of either neuronal depletion or pathway interruption. It would appear that onset events are attributable to a predetermination that self-promotes the initial steps in defining such neurodegeneration.

Affiliation:

University of Malta Medical School Mater Dei Hospital, Malta