Hypotheses and Dynamics in the Pathogenesis of Neurodegenerative Disorders

Indexed in: Scopus, EBSCO.

This book presents a series of clinical and pathologic observations that are thought to contribute to progressive incremental severity in neuronal cell loss and tissue atrophy in the cerebral cortex. ...
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SPECIFICS OF DYNAMICS OF ALZHEIMER DISEASE

Pp. 1-12 (12)

Lawrence M. Agius

Abstract

Estrogens, particularly estradiol-beta, constitute a complexity in hormonereceptivity that evolves via the prevention of delayed cell-death pathways. Neurodegeneration, and ischemic injury to neural tissue, represent a panoramic array of effects that are especially linked to physiologic levels of estradiol-beta. The aging brain, in particular, involves the developmental emergence of immediate gene response that is linked to such estrogen-receptor interactions.

Affiliation:

Mater Dei Hospital Europe.