Latest Findings Of Omega-3 Long Chain Polyunsaturated Fatty Acids: From Molecular Mechanisms To New Applications In Health And Diseases

Indexed in: Scopus, EBSCO.

This E-book covers the main aspects about the benefits of omega-3 long chain polyunsaturated fatty acids (LC-PUFAs) to human health. The knowledge of physiological effects of LC-PUFAs at different ...
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Effects of n-3 Fatty Acids Supplementation on Insulin Resistance

Pp. 46-57 (12)

Maria Teresa Villarreal-Molina and Samuel Canizales-Quinteros


Studies in humans and animal models have demonstrated that fish oil, a natural source of n-3 long chain polyunsaturated fatty acids (LC-PUFA), has clinical significance in the prevention and reversal of insulin resistance. Many studies support that higher proportion of serum and cell-membrane n-3 PUFA can improve insulin sensitivity and prevent type 2 diabetes (T2D). However, epidemiological and dietary intervention studies in healthy, obese and diabetic individuals have produced conflicting results on the metabolic effects of dietary n-3 PUFA. The present chapter discusses updated evidence on this matter, analyzes the possible reasons for these inconsistencies, and the possible mechanisms by which n-3 LC-PUFA may prevent or revert insulin resistance. The use of these fatty acids should be part of integral strategies, considering age, gender, metabolic or health status and other variables. This strategy should include changes in lifestyle, adhering to a healthy diet and regular physical activity. Although this is encouraging in the perspective of insulin resistance prevention, further clinical and basic studies must be designed to confirm and complete our knowledge in this field.


Unit of Molecular Biology and Genomic Medicine, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Departamento de Biología, Facultad de Química, UNAM.