Stem Cell and Regenerative Medicine

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The potential use of stem cells in transplantation for the purpose of tissue regeneration is an exciting area of research currently undergoing rapid development. Implantation of human embryonic or ...
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Therapeutic Angiogenesis for Coronary Artery Disease: Clinical Trials of Proteins, Plasmids, Adenovirus and Stem Cells

Pp. 65-74 (10)

Keith A. Webster

Abstract

Therapeutic angiogenesis represents a molecular and cellular approach to the treatment of CAD that may be an alternative or additive to traditional pharmacology and interventional cardiology. The goal of angiogenic therapy is to activate endogenous angiogenic and arteriogenic pathways and stimulate revascularization of ischemic myocardial tissue. The feasibility of such a strategy has now been established through the results of studies over the past two decades, and clinical trials involving more than 1000 patients have been implemented. In this review we will discuss the results from these trials, tracing the progression of the technology from the delivery of recombinant proteins through gene and stem cell therapies. Critical evaluations reveal that neither proteins nor genes delivered by transient expression vectors provide an optimal therapy. Similarly, stem cell therapy is not achieving the level of improvement that was expected or predicted from preclinical results. The future of therapeutic angiogenesis lies in the use of permanent gene delivery vehicles expressing regulated genes and/or stem cells appropriately engineered with regulated genes.

Affiliation:

Department of Molecular and Cellular Pharmacology and The Vascular Biology Institute, University of Miami School of Medicine, Miami, FL 33136, USA