Frontiers in Drug Design & Discovery

Frontiers in Drug Design & Discovery

Volume: 2

Indexed in: Scopus, EMBASE, EBSCO, Ulrich's Periodicals Directory.

Frontiers in Drug Design and Discovery is a book series devoted to publishing the latest and the most important advances in drug design and discovery. Eminent scientists write contributions on all ...
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NMR-Based Metabonomics of Urine from An Exploratory Study of Ciprofibrate in Healthy Volunteers and Patients with Type 2 Diabete

Pp. 175-191 (17)

Gregory C. Leo, Ewoud J. van Hoogdalem and Martijn B.A. van Doorn

Abstract

This report presents the results from the NMR-based metabonomics of urine collected as part of a multiple dose, double-blind, randomized, placebo controlled parallel group exploratory study of the pharmacodynamics of ciprofibrate in healthy volunteers and patients with type 2 Diabetes Mellitus. Using supervised statistical analysis it was possible to distinguish the various treatment groups (healthy and diabetic: placebo-treated or drug-treated) when males and females were analyzed separately.

Affiliation:

Johnson&Johnson Pharmaceutical Research and Development, LLC, Welsh and McKean Roads, Springhouse, PA 19477-0776, USA.