Frontiers in Natural Product Chemistry

Volume: 1

Indexed in: EBSCO.

“Frontiers in Natural Product Chemistry” is an Ebook series devoted to publishing the latest and most important advances in natural product chemistry. The Ebook series covers all aspects of ...
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Synthesis of Vinblastine Derivatives

Pp. 43-49 (7)

Hedvig Bolcskei, Lajos Szabo and Csaba Szantay

Abstract

The bisindole alkaloids of the Madagascan periwinkle Catharanthus Roseus vincristine 1 and vinblastine 2 are widely used clinically in the chemotherapy of cancer. Many efforts were made to synthesize more efficient new derivatives having less side effects than vinblastine 2. New anhydrovinblastine derivatives were obtained by the ferric chloride mediated coupling reaction of catharanthine and vindoline and their derivatives. The nitro- dinitro-, amino- and hydroxymethyl analogues of the alkaloids 1, 2 and 3 showed promising antitumor activity.

Keywords:

catharanthus roseus, vincristine, antineoplastic agents, chemotherapy, indole alkaloids, nmr study

Affiliation:

Gedeon Richter Ltd. H-1475 Budapest, P.O.B. 27 Hungary, Institute of Organic Chemistry, Budapest University of Technology and Economics, H-1111 Budapest, Gellert ter 4, Hungary.