Frontiers in Natural Product Chemistry

Volume: 1

Indexed in: EBSCO.

“Frontiers in Natural Product Chemistry” is an Ebook series devoted to publishing the latest and most important advances in natural product chemistry. The Ebook series covers all aspects of ...
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Structure and Biological Activity - Diversity Orientated Synthesis

Pp. 31-36 (6)

E. Winterfeldt

Abstract

The cephalostatins ( Cephalodicus gilchristi ) and the agelorins (Agelas oroides ) represent two groups of marine natural products showing high biological activity. The total synthesis of enantiopure analogues reveals for the cephalostatins and the decisive role of molecular dissymmetry and of a chiral curvature, while the agelorins were shown to be prodrugs, which under stress conditions are undergoing an enzymatically induced fragmentation, generating the highly active cyclohexadiene aeroplysinin. Finally a simple diversity oriented enantioselective synthesis of wistarin precursor is reported.

Keywords:

cephalostatins, Cephalodicus gilchristi, agelorins, agelas oroides, enantioselective

Affiliation:

Organic Chemistry Department, Hannover University, Schneiderberg, 1B, D-30167, Hannover, Germany.