Frontiers in CNS Drug Discovery

Volume: 1

Indexed in: Scopus, EMBASE, Book Citation Index, Science Edition, BIOSIS

“Frontiers in CNS Drug Discovery” is an eBook series devoted to publishing the latest and the most important advances in Central Nervous System (CNS) drug design and discovery. Eminent scientists ...
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Drugs and Aggression†

Pp. 206-223 (18)

Alberto A. Rasia-Filho, Marcia Giovenardi and Rosa M.M. de Almeida

Abstract

Aggression is conceived as a social behavior that, in conjunct with motor and visceral displays, is related with acts for obtaining a specific goal or is directed against threatening stimuli with the intention of causing harm, either for attack or defense. Here it is reviewed basic concepts and aspects for the classification of aggression, the behavioral displays regarded as aggressive in animal models, the basic neural circuits that are involved to them and the pharmacological approaches involving some neurotransmitters (5-HT, dopamine and GABA) and drugs that can be used to identify the neural basis of aggression and to modulate its expression. Data are based on experiments developed mainly with rodents; however, some updated research hypotheses that may well give some insights for the clinical sciences in men were also included.

Keywords:

Aggressive behavior, brain circuits, amygdaloid complex, medial amygdala, neurotransmitters, psychopharmacology, dopamine, GABA, serotonin

Affiliation:

Universidade Federal de Ciencias da Saude de Porto Alegre, Department of Basic Sciences and/or Program in Health Sciences, R. Sarmento Leite 245, Porto Alegre, RS 90050-170, Brazil.