Frontiers in CNS Drug Discovery

Volume: 1

Indexed in: Scopus, EMBASE, Book Citation Index, Science Edition, BIOSIS

“Frontiers in CNS Drug Discovery” is an eBook series devoted to publishing the latest and the most important advances in Central Nervous System (CNS) drug design and discovery. Eminent scientists ...
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Pharmacological Treatment for Parkinson's Disease: A Continuing Evolution

Pp. 147-155 (9)

Quincy J. Almeida and H. Christopher Hyson

Abstract

Since the introduction of levodopa therapy in the 60's, there has yet to be a more efficacious drug identified for the symptomatic treatment of Parkinson's disease (PD). Perhaps more importantly, there has been little to no success finding agents that have proven effective in protecting against neurodegeneration. In fact, recent development efforts have been primarily directed at stabilizing the side effects (wearing off, drug-induced dyskinesias, motor fluctuations) that accompany prolonged levodopa therapy, such as catechol O-methyltransferase inhibition to combat the side effects of levodopa therapy.

This review also examines alternative strategies to levodopa therapy, including potential adjuncts therapies, recent patents and future directions to be evaluated for neuroprotection. While dopamine agonists are inferior to levodopa in controlling motor symptoms, potential benefits and drawbacks with this class of drugs are presented. Potential neuroprotective agents such as monoamine oxidase-B inhibitors are also examined for their therapeutic benefit as well as their potential to slow disease progression. Neuroprotection will continue to be an important area of research in CNS drug development.

Keywords:

Parkinson's disease, basal ganglia, dopamine, movement disorder, dopamine agonist, monoamine oxidase inhibitor, treatment, medication

Affiliation:

Sun Life Financial Movement Disorders Research and Rehabilitation Centre, Faculty of Science, BA-515, Wilfrid Laurier University, 75 University Ave. W. Waterloo ON N2L 3C5, Canada.