Frontiers in Cardiovascular Drug Discovery

Frontiers in Cardiovascular Drug Discovery

Volume: 1

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“Frontiers in Cardiovascular Drug Discovery” is an eBook series devoted to publishing the latest and the most important advances in Cardiovascular drug design and discovery. Eminent scientists ...
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Urokinase-An Important Anti-Thromboembolic Drug

Pp. 212-235 (24)

Adinarayana Kunamneni, Bhavani D. Ravuri, Vinjamuri Saisha, Poluri Ellaiah and Taadimalla Prabhakhar

Abstract

Urokinase (UK) [EC 3.4.99.26] is a serine protease that activates plasminogen to plasmin, which in turn degrades fibrin clots. Plasmin has diverse physiological roles apart from its fibrinolytic role in the regulation of blood clotting. It has been implicated in complement activation, cell migration, wound healing, and generation of localized extracellular proteolysis during tissue remodelling, pro-hormone conversion, carcinogenesis and neoplasia. Among the plasminogen activators, UK provides a superior alternative for the simple reasons of its being more potent as compared to tissue-plasminogen activator and nonantigenic by virtue of its human origin unlike streptokinase. Based on these observations, UK is an important anti-thromboembolic drug. Hence, UK, as one of the most potent plasminogen activators is attracting a great deal of attention. In this chapter, we will summarize recent patents related to the occurrence, mechanism of action, structure and function, physico-chemical properties, in vitro production, cloning and expression, purification and applications of UK.

Keywords:

Urokinase (UK), plasminogen activators, fibrinolysis, cardiovascular agent, production, cloning and expression, purification, physico-chemical properties and applications

Affiliation:

Pharmaceutical Biotechnology Division, University College of Pharmaceutical Sciences, Andhra University, Visakhapatnam-530 003, India