Frontiers in Cardiovascular Drug Discovery

Frontiers in Cardiovascular Drug Discovery

Volume: 1

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“Frontiers in Cardiovascular Drug Discovery” is an eBook series devoted to publishing the latest and the most important advances in Cardiovascular drug design and discovery. Eminent scientists ...
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The Clinical Impact of Hyperphosphatemia in Chronic Kidney Disease Patients: The Role of Lanthanum Carbonate

Pp. 154-164 (11)

Mario Cozzolino and Diego Brancaccio

Abstract

Vascular calcification is a very common event in patients affected by diabetes and chronic kidney disease (CKD). Recently, it has been well documented that abnormalities in mineral and bone metabolism in CKD patients associate with increased morbidity and mortality. Elevated serum phosphate and calciumphosphate product levels play an important role in the pathogenesis of vascular mineralization in uremic patients and also appear to be associated with increased cardiovascular mortality. Together with classical passive precipitation of calciumphosphate in soft tissues, during the last decade it has been demonstrated that inorganic phosphate may cause extraskeletal calcification directly through a real “ossification” of the tunica media in the vasculature of CKD patients. Therefore, control of phosphate retention is now an even more crucial target of treatment in patients affected by chronic kidney disease. The “classical” treatment of secondary hyperparathyroidism and hyperphosphatemia in CKD patients consists of either calcium or aluminium based phosphate-binders and calcitriol administration. Unfortunately, this “old generation” therapy is not free of complications. Lanthanum carbonate represents a novel phosphate binder used for the treatment of hyperphosphataemia in patients with renal failure. This new calcium- and aluminium-free phosphate binder can be used to treat hyperphosphatemia and secondary hyperparathyroidism, reduce atherosclerotic process, and prevent vascular calcification in CKD.

Keywords:

Phosphate-binders, lanthanum carbonate, vascular calcification, secondary hyperparathyroidism, dialysis

Affiliation:

Renal Division, S. Paolo Hospital, University of Milan, Italy