Frontiers in Anti-Infective Drug Discovery

Volume: 1

Indexed in: Scopus, Book Citation Index, Science (BKCI-S), Web of Science, BIOSIS Previews, EMBASE, Chemical , EBSCO, Ulrich's Periodicals Directory.

“Frontiers in Anti-Infective Drug Discovery” is an eBook series devoted to publishing the latest and the most important advances in Anti-Infective drug design and discovery. Eminent scientists ...
[view complete introduction]

US $
15

*(Excluding Mailing and Handling)



Antibacterial Properties of Organosulfur Anti-Infectives: A Review of Patent Literature 1999-2009

Pp. 269-278 (10)

Monika I. Konaklieva and Balbina J. Plotkin

Abstract

A wide variety of organosulfur compounds that exhibit antibacterial properties are being patented. Functionally, organosulfur groups can act as metal chelators, powerful nucleophiles, or electrophiles depending on the local reaction environment. In this review of patent literature from 1999-2009, the reliance of these compounds on the reaction of the sulfur moiety with its biological target(s) will be discussed with regards to activity, specificity, and antimicrobial spectrum.

Affiliation:

Department of Chemistry, American University, 4400 Massachusetts Avenue, NW, Washington, DC 20016-8014, USA