Frontiers in Anti-Infective Drug Discovery

Volume: 1

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“Frontiers in Anti-Infective Drug Discovery” is an eBook series devoted to publishing the latest and the most important advances in Anti-Infective drug design and discovery. Eminent scientists ...
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Strategies for Effective Naked-DNA Vaccination Against Infectious Diseases

Pp. 1-16 (16)

Pieranna Chiarella, Emanuela Massi, Mariangela De Robertis, Vito M. Fazio and Emanuela Signori

Abstract

To date, vaccination is an active area of investigation for its application to a great variety of human diseases including infections and cancer. In particular, naked-DNA vaccination has arisen as effective strategy in the preventive medicine field with promising future prospects. The ability of plasmid DNA to activate the humoural and the cellular arms of the immune system against the encoded antigen have resulted in intensive study of new strategies aimed at increasing the DNA vaccine immunogenicity. Nevertheless, plasmid-based vaccines emerged as a safer and advantageous alternative with respect to viral vector vaccines. Recent advances in both the immunological and biotechnological research field made it possible to enhance significantly the DNA vaccine potency. Most of these approaches are based on both the discovery of novel delivery systems and the implementation of plasmid constructs, achieved through genetic engineering. In this review, we will describe some of the most relevant patents issued in the last ten years, supporting the progress made in naked-DNA vaccination against infectious diseases.

Keywords:

DNA vaccines, human infectious diseases, gene therapy, naked DNA, delivery systems, adjuvant, plasmid vector

Affiliation:

Laboratory of Molecular Medicine and Biotechnology, CIR, Campus Bio-MedicoUniversity of Rome, Via Alvaro del Portillo 21 - 00128 Rome, Italy