Frontiers in Anti-Cancer Drug Discovery

Volume: 1

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“Frontiers in Anti-Cancer Drug Discovery” is an eBook series devoted to publishing the latest and the most important advances in Anti-Cancer drug design and discovery. Eminent scientists write ...
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Targeting Vesicle Trafficking in Cancer Therapeutics

Pp. 758-776 (19)

Paul K. Wright

Abstract

Cancer is a common disease in Western society that can affect any organ system. It has a high morbidity and mortality despite advances in treatment over the last hundred years. There is a clear need for new approaches to cancer chemotherapy including the possibility of reducing systemic adverse effects associated with current treatments. Vesicle trafficking is an essential cellular process that is perhaps not fully recognized. There is mounting evidence that vesicle trafficking, including the release of extracellular microvesicles, is a highly important process in tumourigenesis. Diverse aspects of tumourigenesis including invasion, metastasis, cell cycle regulation, angiogenesis, tumour immune privilege, neoplastic coagulopathy and multidrug resistance can be explained by altered vesicle trafficking in cancer cells. This paper reviews the evidence in the scientific and patent literature for the role of vesicle trafficking in tumourigenesis and suggests a number of targets and strategies that may be important for cancer therapeutics.

Keywords:

Vesicle trafficking, cancer, chemotherapy, multidrug resistance, vesicle, exosome, microvesicle, microparticle, membrane vesicle, exocytosis, endocytosis, metastasis, invasion, angiogenesis, Rab, secretion

Affiliation:

Department of Histopathology, Clinical Sciences Building, 1st Floor, Manchester Royal Infirmary, Oxford Road, Manchester, M13 9WL, UK.