Review of Selected Patents for Cancer Therapy Targeting: Tumor Angiogenesis
Pp. 741-757 (17)
Mark N. Kirstein and Arkadiusz Z. Dudek
Targeting tumor angiogenesis to treat cancer has been the focus of intense research in recent decades. The resulting increase in our knowledge of cancer biology has lead to the development of several new classes of investigational agents that inhibit the angiogenic process. While many clinical trials on antiangiogenic compounds have had disappointing results, the recent approval of the first effective drug targeting tumor vessels has revived interest in further drug development for angiogenesis inhibitors. Of the plethora of new patents for antiangiogenic compounds, only a few describe compounds that will become effective and with tolerable toxicity therapies for patients with cancer. This review examines representative patents related to cancer angiogenesis in the context of our current knowledge of the biological processes leading to tumor vascularization and explores the future of multi-targeted therapy in the field of angiogenic therapy.
Tumor angiogenesis, vascular endothelial growth factor, indolinones
Department of Experimental and Clinical Pharmacology, College of Pharmacy and Masonic Comprehensive Cancer Center, University of Minnesota, USA.