Advances in Organic Synthesis

Volume: 2

Modern Organofluorine Chemistry-Synthetic Aspects

Indexed in: Scopus, Chemical Abstracts, EBSCO, Ulrich's Periodicals Directory

The volume focuses on recent advances in organofluorine chemistry directed towards selective fluorine introduction into various target molecules, employing both traditional and contemporary, ...
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Enantioselective Electrophilic Fluorination: The Complete Story

Pp. 431-461 (31)

C. Audouard, J. -A. Ma and D. Cahard

Abstract

Progress in the field of enantioselective electrophilic fluorination during the past eighteen years resulting from fascinating research conducted by twelve international groups is reviewed. Two complementary strategies for the synthesis of enantiopure fluorine-containing molecules currently define state-of-the-art in this area. The use of chiral, non-racemic fluorinating agents is the most general approach while catalytic methods using either transition-metal catalysts or organocatalysts apply to specific substrates.

Affiliation:

UMR 6014 CNRS, Institut de Recherche en Chimie Organique Fine (IRCOF) Universite de Rouen, F-76821 Mont Saint Aignan Cedex, France.