Advances in Organic Synthesis

The volume focuses on recent advances in organofluorine chemistry directed towards selective fluorine introduction into various target molecules, employing both traditional and contemporary, electroph...
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Biocatalysis in Organic Synthesis

Pp. 455-518 (64)

Robert Azerad

Abstract

Biocatalytic reactions using enzymes or whole microbial cells are increasingly employed for organic synthesis, taking advantage of their high versatility and exquisite selectivities (chemo-, regio- and stereoselectivity). Resolution of racemates and its refinements, desymmetrisation of meso- and prochiral compounds by oxidoreduction, some C-C bond forming reactions and other miscellaneous reactions will be outlined, illustrating the most characteristic aspects of environmentally friendly and yield-effective production of commodity chemicals, stereospecific building blocks or intermediates, and competitive step-replacement strategies for asymmetric syntheses.

Affiliation:

Groupe de Biocatalyse, Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR CNRS 8601, Universite Rene Descartes-Paris V, 45 rue des Saints Peres, 75006 Paris, France.