Advances in Organic Synthesis

Advances in Organic Synthesis

The volume focuses on recent advances in organofluorine chemistry directed towards selective fluorine introduction into various target molecules, employing both traditional and contemporary, electroph
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Biocatalysis in Organic Synthesis

Pp. 455-518 (64)

Robert Azerad


Biocatalytic reactions using enzymes or whole microbial cells are increasingly employed for organic synthesis, taking advantage of their high versatility and exquisite selectivities (chemo-, regio- and stereoselectivity). Resolution of racemates and its refinements, desymmetrisation of meso- and prochiral compounds by oxidoreduction, some C-C bond forming reactions and other miscellaneous reactions will be outlined, illustrating the most characteristic aspects of environmentally friendly and yield-effective production of commodity chemicals, stereospecific building blocks or intermediates, and competitive step-replacement strategies for asymmetric syntheses.


Groupe de Biocatalyse, Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, UMR CNRS 8601, Universite Rene Descartes-Paris V, 45 rue des Saints Peres, 75006 Paris, France.