Advances in Organic Synthesis

Volume: 1

Indexed in: Scopus, Chemical Abstracts, EBSCO, Ulrich's Periodicals Directory

Advances in Organic Synthesis is a book series devoted to the latest advances in synthetic approaches towards challenging structures. It presents comprehensive articles written by eminent authorities ...
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Pressure Activation in Organic Synthesis

Pp. 25-80 (56)

Gerard Jenner

Abstract

High pressure activation is presented as a potent synthetic strategy depending on the magnitude of the activation volume. Coupling of high pressure with ancillary activation methods such as catalysis widens the methodology. The application fields are reviewed: Diels-Alder reactions, 1,3- dipolar cycloadditions, [2+2] cycloadditions, Michael and related reactions, Baylis-Hillman additions etc... Many valuable substances can be synthesized in this way. Some recent developments are outlined, directed toward generation of pressure by water freezing, supramolecular chemistry, inhibition of steric hindrance.

Affiliation:

Laboratoire de Piezochimie Organique (UMR CNRS 7123), Faculte de Chimie, Universite Louis Pasteur, 67008 Strasbou France.