Molecular Aspects of Neurodegeneration and Neuroprotection

Indexed in: Scopus, Chemical Abstracts, EBSCO.

Neurodegenerative diseases are a complex heterogeneous group of diseases associated with site-specific premature and slow death of certain neuronal populations in brain and spinal cord tissues. For ...
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Future Perspective: Directions for Future Development on Various Aspects of Neurodegeneration and Neuroprotection in Neurological Disorders

Pp. 132-139 (8)

Akhlaq A. Farooqui and Tahira Farooqui

Abstract

Neuronal cell death in neurodegenerative and neurotraumatic diseases is accompanied by excitotoxicity, oxidative stress, and inflammation. These processes lead to the generation of lipid mediators. The intensity of cross talk among lipid mediators dictates the rate of neurodegeneration in above neurological diseases. In neurodegenerative diseases cell death occurs slowly (months to years), where as in neurotraumatic diseases, neurodegeneration occurs rapidly (minutes to hours) through necrosis at the core of injury, whereas in penumbral region neurons undergo delayed neurodegeneration through apoptosis. Presence of lipid mediators in biological fluids can be used for the diagnosis of above neurological disorders.

Keywords:

Neurodegeneration; neuroprotection; neurological disorders; apoptosis; oxidative stress; inflammation; excitotoxicity; lipid mediators

Affiliation:

Department of Molecular and Cellular Biochemistry.