Amelogenins: Multifaceted Proteins for Dental and Bone Formation and Repair

Indexed in: Chemical Abstracts, EBSCO, Ulrich's Periodicals Directory

This volume is the 1st in a series of Ebooks that bridges the gap between advances in science and clinical practice in odontology. Recent advances in biology, materials science and tissue engineering ...
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Clinical Applications of an Enamel Matrix Protein Derivative in Regenerative Periodontal Therapy

Pp. 214-228 (15)

Anton Sculean, Dieter D. Bosshardt and Michel Brecx


The goal of regenerative periodontal therapy is the reconstitution of the lost periodontal structures (i.e. the new formation of root cementum, periodontal ligament and alveolar bone). Findings from basic research have pointed to the important role of an enamel matrix protein derivative (EMD) in periodontal wound healing. Histological results from acute and chronic animal models and from human case reports have provided evidence that treatment with EMD may indeed promote periodontal regeneration and positively influences wound healing in intrabony, class II furcation and recession type defects. Recent long-term randomized controlled clinical studies have demonstrated that the improvements obtained following surgery with EMD can be maintained on a long term basis. The aim of the present chapter is to provide an overwiev on the clinical applications for EMD in regenerative periodontal therapy.


Enamel Matrix Derivative, Regenerative Periodontal Therapy, Periodontal Regeneration, Human Histology, Clinical Trials


Department of Periodontology, University of Bern, Bern, Switzerland.