Amelogenins: Multifaceted Proteins for Dental and Bone Formation and Repair

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This volume is the 1st in a series of Ebooks that bridges the gap between advances in science and clinical practice in odontology. Recent advances in biology, materials science and tissue engineering ...
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Lessons from the Amelogenin Knockout Mice

Pp. 25-31 (7)

Naoto Haruyama, Junko Hatakeyama, Yuji Hatakeyama, Carolyn W. Gibson and Ashok B. Kulkarni

Abstract

Although others and we have earlier reported that the amelogenins play critical roles in proper enamel formation, the in vivo functions of each of the amelogenin isoforms have not been clearly defined because of their heterogeneity and complexity. This chapter will review the current information on the functions of amelogenin splice isoforms, full length amelogenin and leucine rich amelogenin peptide (LRAP), in enamel formation. We will also discuss the emerging evidence for the additional role of LRAP as a signaling molecule in mesenchymal cells of the periodontal tissues. We believe that further insights into the signaling pathway modulated by the multifunctional amelogenin proteins will lead to development of new therapeutic approaches to treat dental diseases and disorders.

Keywords:

Amelogenin, Mouse Model, M180, Leucine rich Amelogenin Peptide (LRAP), Signaling Molecules

Affiliation:

Global Center of Excellence Program, International Research Center for Molecular Science in Tooth and Bone Diseases.