Network Approaches to Diseases of the Brain

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This book covers novel approaches using networks and oscillations and it will serve as a catalyst for translating these exciting advancements into the clinical arena. This collection of articles aims ...
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Neural Networks in the Developing Human Brain

Pp. 21-31 (11)

Catherine J. Chu-Shore, Verne S. Caviness and Sydney S. Cash


The brain undergoes massive and exquisitely controlled age-specific anatomical and physiological changes throughout development. The network paradigms discussed in this chapter provide a rich new method to track these dynamic interregional relationships and describe global properties of the developing system as a whole. Here, as background, we review the primary events of anatomical and physiological neurodevelopment from gestation through adolescence. We then describe early work elucidating the presence and evolution of agespecific functional brain networks in normal neurodevelopment. Finally, we discuss work aimed at understanding how these relationships may be altered in disease, and perhaps even rectified with treatment. Although much remains to be done, the application of the network model to the developing human brain holds tremendous promise for future discovery.


Pruning, maturation, neuroanatomy, default network, epilepsy, autism.


Divisions of Pediatric Neurology and Neurophysiology, Department of Neurology, Massachusetts General Hospital, 175 Cambridge Street, Suite 340, Boston, MA 02114, USA