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Advances in Biomedical Sciences and Engineering
Editor(s): S.C Tjong
eISBN: 978-1-60805-040-6   ISBN: 978-1-60805-607-1   
Indexed in: Scopus
Chapter PDF Price: US $15
   



Synthesis and Properties of Nano-Hydroxyapatite/ Polymer Nanocomposites for Bone Tissue Engineering

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Author(s): Sie Chin Tjong
Chapter DOI: 10.2174/978160805040610901010082
Page: 82-142 (61)

Abstract:
Hydroxyapatite (HA) is the main mineral constituent of human bones. HA nanocrystals can be synthesized using a variety of wet solution methods including chemical precipitation, hydrothermal, sol-gel, micro- and nano-emulsion. HA nanocrystals synthesized from the chemical precipitation process generally exhibit plate-like morphology. They tend to self-organize into an ordered structure in the presence of biopolymers. The self-assembled HA-polymer nanocomposites simulate the hierarchical structure of human bone at a fundamental level. Such biomimetic nanocomposites favor osteoblast adhesion and proliferation, thereby stimulating new bone growth. Proper understanding of the biomineralization of self-assembled structures is needed for designing high performance polymer nanocomposites in bone tissue engineering.
Keywords:
Bone, hydroxyapatite, nanocrystal, polymer, precipitation, self-assembly, biocompatibility, biomimetic structure, scaffold, electrospinning
Affiliation:
Department of Physics & Materials Science, City University of Hong Kong, Tat Chee Avenue, Kowloon, Hong Kong.