Biology of Bone
Pp. 7-27 (21)
Anastasios K. Markopoulos
Bones are rigid organs that form part of the endoskeleton of vertebrates. They function to
move, support, and protect the various organs of the body, produce red and white blood cells and store
minerals. This chapter briefly covers a wide spectrum of areas related to elementary bone
pathophysiological features and basic bone research. While bone embryology, osteogenesis, bone
remodeling, bone development, osteoblast and osteoclast biology constitute the main contents, topics
important to the understanding of bone metabolic diseases are also reviewed. The significance of bone
enhancing factors and effect of immune system on bone is discussed. Elementary knowledge is also
given for the relation of bone and implants.
Aristotle University of Thessaloniki.