Anti-Obesity Drug Discovery and Development

Anti-Obesity Drug Discovery and Development

Volume: 1

Indexed in: Chemical Abstracts, EBSCO, Ulrich's Periodicals Directory, Scopus

Obesity is a complex health problem, caused by a number of factors such as excessive food intake, lack of physical activity, genetic predisposition, endocrine disorders, medications and psychiatric ...
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The Search for New Anti-Obesity Agents to Reduce Cardiometabolic Risk

Pp. 96-113 (18)

Cynthia Arbeeny

Abstract

The global epidemic of obesity is rapidly accelerating in both industrialized and developing countries, and has raised significant healthcare concerns worldwide. Obesity leads to numerous co-morbidities, including cardiovascular diseases (CVD), type 2 diabetes (T2D), hypertension, certain cancers, and sleep apnea. Obesity is considered an independent risk factor for CVD, and is associated with dyslipidemia, hypertension, glucose intolerance and inflammatory markers; all of which contribute to CV risk. The benefits of weight reduction to decrease cardiometabolic risk are well-documented, yet long term weight loss has been difficult to achieve. This has lead to intense efforts within the pharmaceutical industry to develop agents that result in weight loss and prevent weight regain. Numerous strategies have been directed toward decreasing food intake and/or increasing energy expenditure, yet this has met with limited success in developing a safe and effective drug. This review summarizes the underlying mechanisms contributing to CV risk in obesity, and discusses the targets that may result in novel pharmacological agents that can sustain weight loss and reduce cardio-vascular morbidity and mortality.

Keywords:

Obesity, weight loss, adipose tissue, metabolic syndrome, cardiovascular disease.

Affiliation:

Vice President Endocrine and Metabolic Diseases, Genzyme Corporation, 49 New York Ave., Framingham MA 01701-9322, USA.