Nephrology and Clinical Chemistry: The Essential Link

Indexed in: Scopus, EBSCO.

Clinical chemistry is a science that requires specific knowledge and teaching. The e-book covers several topics in clinical nephrology. Patients suffering from severe chronic kidney disease may be ...
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Vascular Calcifications in Chronic Kidney Disease: Can the Biologist be of Some Help?

Pp. 122-133 (12)

Anne-Sophie Bargnoux, Marion Morena, Anne-Marie Dupuy, Etienne Cavalier, Georges Mourad, Pierre Delanaye, Bernard Canaud and Jean-Paul Cristol

Abstract

Vascular calcifications constitute an important risk factor for mortality in chronic kidney disease patients. A better knowledge of physiopathologic phenomena responsible for vascular mineralization leads to emerging biological markers of vascular calcifications. In calcified arteries, presence of bone matrix as well as osteoblast and osteoclast cells suggests that vascular calcification is an active and highly regulated process. In uremic environment, vascular smooth muscle cells can transdifferentiate into osteoblast like cells. The OPG/RANK/RANKL system is clearly of central significance in controlling vascular calcifications as in bone metabolism. Converging results suggest that circulating OPG determination should be a relevant marker of calcifications. Impairment in inhibitory system such as Matrix Gla Protein and fetuin-A promotes bone matrix calcification. Finally, FGF23, an early and sensitive marker of bone and mineral disorders in chronic kidney disease patients appears as a promising marker.

Keywords:

Vascular calcification, fetuin A, FGF-23

Affiliation:

Department of Biochemistry, Lapeyronie University Hospital, 191 Avenue du Doyen Gaston Giraud, 34295 Montpellier cedex 5, France.