Molecular Oncology: Principles and Recent Advances

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Cancer is one of the major causes of death worldwide. Despite hundreds of clinical trials currently in progress for cancer patients, the success rate is still very low. Understanding the molecular ...
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IV. Example 1: Hepatocellular Carcinoma

Pp. 44-47 (4)

Pablo Muriel

Abstract

Primary liver cancer is the sixth most common cancer in the world and the third cause of death by cancer due to its bad prognosis. Most primary liver cancers are Hepatocellular Carcinomas (HCC). The major risk factors for HCC are chronic liver diseases (especially cirrhosis) including hepatitis B and C, alcoholic liver disease, non-alcoholic steatohepatitis, estrogens, and well documented environmental preventable risk factors, among others. Rho, hepatocyte growth factor, and metalloproteinases are associated with metastasis and death from HCC.

Keywords:

Cancer, fibrosis, necrosis, cirrhosis NF-κB, alcoholic liver disease, metalloproteinases, HBV, HCV, aflatoxins, hemochromatosis.

Affiliation:

Department of Pharmacology, Centro de Investigacion y de Estudios Avanzados del I.P.N., Avenida Instituto Politecnico Nacional 2508, 07360 Mexico City, Mexico.