Molecular Oncology: Principles and Recent Advances

Indexed in: Scopus

Cancer is one of the major causes of death worldwide. Despite hundreds of clinical trials currently in progress for cancer patients, the success rate is still very low. Understanding the molecular ...
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II. Obesity and Cancer

Pp. 28-32 (5)

Ranier Gutierrez

Abstract

Obesity is the largest pandemic, the human being has undergone. Obesity has been linked to several health-related problems, but recent epidemiological studies have uncovered a link between excess body weight and certain types of cancers. We have begun to realize the complexity of the biological mechanisms that link obesity and being overweight to many forms of cancer. In this chapter, I briefly review these epidemiological findings and the three molecular pathways currently proposed to link body weight gain and cancer risk. Despite the fact that these molecular pathways, vary and depend on both sex and the type of cancer, I briefly discuss the possible roles of three hormonal systems, the adipose derived hormones, the Insulin-Like Growth Factor (IGF) axis and sex steroids, in linking obesity and cancer risk.

Keywords:

Adiponectin, leptin, insulin, insulin-like growth factor, IGFBP, sex steroids, SHBG obesity, cancer.

Affiliation:

Department of Pharmacology, Centro de Investigacion y de Estudios Avanzados del I.P.N., Avenida Instituto Politecnico Nacional 2508, 07360 Mexico City, Mexico.