Cell Proliferation, Differentiation and Apoptosis
Pp. 3-17 (15)
Miriam Huerta, Carla Angulo and Esther López-Bayghen
Tight control of the cell cycle in eukaryotic cells exists to control proliferation, differentiation or
apoptosis. These processes model and shape tissue and organ relationships in multicellular organisms. Two
biochemical processes, protein phosphorylation/dephosphorylation and ubiquitin-mediated degradation drive cell
cycle control. A multitude of pathways control cyclin-dependent kinase activities as the major event for cell cycle
progression. Differentiation and apoptosis have cell cycle withdraw in common, while cancer and degenerative
processes both show altered control of the cell cycle.
Cell cycle, cancer, cyclins, apoptosis, check points, caspase, senescence, Bcl-2, cell differentiation,
Department of Genetics and Molecular Biology, Centro de Investigación y de Estudios Avanzados del I.P.N., Avenida Instituto Politécnico Nacional 2508, 07360 Mexico City, Mexico.