Molecular Oncology: Principles and Recent Advances

Indexed in: Scopus

Cancer is one of the major causes of death worldwide. Despite hundreds of clinical trials currently in progress for cancer patients, the success rate is still very low. Understanding the molecular ...
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Cell Proliferation, Differentiation and Apoptosis

Pp. 3-17 (15)

Miriam Huerta, Carla Angulo and Esther López-Bayghen

Abstract

Tight control of the cell cycle in eukaryotic cells exists to control proliferation, differentiation or apoptosis. These processes model and shape tissue and organ relationships in multicellular organisms. Two biochemical processes, protein phosphorylation/dephosphorylation and ubiquitin-mediated degradation drive cell cycle control. A multitude of pathways control cyclin-dependent kinase activities as the major event for cell cycle progression. Differentiation and apoptosis have cell cycle withdraw in common, while cancer and degenerative processes both show altered control of the cell cycle.

Keywords:

Cell cycle, cancer, cyclins, apoptosis, check points, caspase, senescence, Bcl-2, cell differentiation, cyclin-dependent kinase.

Affiliation:

Department of Genetics and Molecular Biology, Centro de Investigación y de Estudios Avanzados del I.P.N., Avenida Instituto Politécnico Nacional 2508, 07360 Mexico City, Mexico.