Physiopathogenesis of Hematological Cancer

Indexed in: Scopus, EBSCO.

The number of new discoveries related to diagnostics and therapeutics of hematological cancer is significant. These have resulted in continuous progress in fundamental knowledge about molecular and ...
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Transcription Factors in Hematological Malignancies

Pp. 78-102 (25)

Estela Maria Novak and Durvanei Augusto Maria

Abstract

Transcription factors are key regulators of the pattern of gene expression in a cell and directly control central processes such as proliferation, survival, self-renewal, and invasion. Alterations in the mechanisms that normally control these functions can lead to hematological malignancies. This chapter will describe the highlights of the main transcription factors in hematological malignancies.

Keywords:

Hypoxia-Inducible Factors (HIF-1), Nuclear Factor-κB (NF-κB), Signal Transducer and Activator of Transcription (STAT), Homeobox (HOX), Lymphoma, Myelodysplastic Syndromes, Leukemia, NUP98-HOXA9, Multiple Myeloma, Therapeutic Strategies.

Affiliation:

Divisão de Pesquisa em Biologia Molecular da Fundação Pró-Sangue, Hemocentro of Seo Paulo, Av. Dr. Eneas Carvalho Aguiar 155, 1 andar, 05403-000 Sao Paulo, SP, Brazil.