Transcription Factors in Hematological Malignancies
Pp. 78-102 (25)
Estela Maria Novak and Durvanei Augusto Maria
Transcription factors are key regulators of the pattern of gene expression in a cell and
directly control central processes such as proliferation, survival, self-renewal, and invasion. Alterations
in the mechanisms that normally control these functions can lead to hematological malignancies. This
chapter will describe the highlights of the main transcription factors in hematological malignancies.
Hypoxia-Inducible Factors (HIF-1), Nuclear Factor-κB (NF-κB), Signal Transducer and
Activator of Transcription (STAT), Homeobox (HOX), Lymphoma, Myelodysplastic Syndromes,
Leukemia, NUP98-HOXA9, Multiple Myeloma, Therapeutic Strategies.
Divisão de Pesquisa em Biologia Molecular da Fundação Pró-Sangue, Hemocentro of Seo Paulo, Av. Dr. Eneas Carvalho Aguiar 155, 1 andar, 05403-000 Sao Paulo, SP, Brazil.