Cancer Stem Cells
Pp. 10-13 (4)
Sara T. O. Saad
Recent studies have demonstrated that tumor cells have hierarchical organization with cancer
stem cells at the apex. Cancer stem cells, also termed cancer initiating cells, have self-renewal capacity and
might not be sensitive to cytotoxic drugs. Thus, these cells may be responsible for the high frequency of
relapse in many cancers, such as acute leukemias, brain and breast cancer. This chapter will approach the
evidences of the presence of leukemia stem cells and the therapeutic perspectives to reach these cells.
Cancer stem cells, Hematopoietic Stem Cell (HSC), Leukemia Stem Cells (LSCs), Primitive
Hematopoietic Cell, Normal Hematopoiesis, AML, CML, Epithelial–Mesenchymal Transition (EMT),
Osteopontin (OPN), Therapeutic Opportunities.
Departamento de Clínica Medica. Faculdade de Ciencias Medicas. Universidade Estadual de Campinas, Cid. Universitaria Zeferino Vaz Cx. Postal 6198 - Campinas, SP. Brazil.