Roles for NF-κB in Regulating Gene Expression in Synaptic Plasticity and Memory
Pp. 66-78 (13)
Gary Odero, Wanda Snow, Kunjumon Vadakkan and Benedict C. Albensi
Changing the strength of synaptic connections between neurons is a process by which memory traces
are encoded and stored in the nervous system. Evidence to date suggests that long term memory encoding and
storage are dependent on mRNA translation and protein synthesis. Studies over the years have identified key
signaling molecules involved in processes of protein synthesis in contexts of long term memory. Transcription
factors, such as cAMP response element binding (CREB) protein, CCAAT/enhancer binding protein (C/EBP),
early growth response (Egr) protein, activator protein 1 (AP-1), and nuclear factor kappa B (NF-κB) have been
hypothesized to play roles in memory suggesting that these molecules function as part of a sophisticated response
for processes of protein synthesis in long term memory. Previous studies have shown roles for some of these
proteins in CNS disorders, where a rapidly growing literature supports the involvement of NF-κB, not only in
neurodegenerative conditions, but also in synaptic plasticity and memory.
NF-kB, synaptic plasticity, memory, TNF, transcription factor, gene expression, Egr, translation,
transcription, neuron, hippocampus, LTP, LTD.
351 Tache Ave, St. Boniface Research Centre, R4050. Winnipeg, Manitoba R2H 2A6 Canada.