Transcription Factors CREB and NF-κB: Involvement in Synaptic Plasticity and Memory Formation

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The main theme of this book is to critically survey the role of two recognized protein molecules (i.e., transcription factors) in processes of human memory. In addition, authors provided recent data ...
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The Role of CREB in Neuronal Plasticity, Learning and Memory, and in Neuropsychiatric Disorders

Pp. 22-42 (21)

Angela Fontan-Lozano, Rocio Romero-Granados, Eva M. Perez-Villegas and Angel M. Carrion

Abstract

A characteristic of higher organisms is their ability to learn by experience in order to adapt their behaviour. Such plasticity is largely the result of the brain’s ability to convert transient stimuli into long-lasting alterations in neuronal structure and function. This process is complex and involves changes in receptor trafficking, local mRNA translation, protein turnover and gene synthesis. Here, we will review how changes in neuronal activity trigger CREB-dependent gene expression in order to provoke more persistent changes in neuronal function. Interestingly, CREB activity is altered in some psychiatric disorder such as anxiety and depression, which suggest that this programme is essential for the correct functioning of the brain.

Keywords:

Transcription factors, CREB, CBP, CREB target genes, Acetylation, Transduction signaling, Learning, Long-term memory, Consolidation, LTP, Neurodegeneration, Anxiety, Depression.

Affiliation:

Division de Neurociencias, Universidad Pablo de Olavide, Carretera de Utrera Km. 1, Sevilla- 41013, Spain.