SARS-CoV-2: Recent Reports on Antiviral Therapies Based on Lopi- navir/Ritonavir, Darunavir/Umifenovir, Hydroxychloroquine, Remde- sivir, Favipiravir and Other Drugs for the Treatment of the New Coronavirus

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Author(s): Michele Costanzo, Maria Anna Rachele De Giglio, Giovanni Nicola Roviello*.

Journal Name: Current Medicinal Chemistry

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Here we report on the most recent updates on experimental drugs successfully em- ployed in the treatment of the disease caused by SARS-CoV-2 coronavirus, also referred to as COVID-19 (COronaVIrus Disease 19). In particular, several cases of recovered patients have been reported after being treated with lopinavir/ritonavir (which is widely used to treat human immunodeficiency virus (HIV) infection) in combination with the anti-flu drug oseltamivir. In addition, remdesivir, which has been previously administered to Ebola virus patients, has also proven effective in the U.S. against coronavirus, while antimalarial chloroquine and hydroxy- chloroquine, favipiravir and co-administered darunavir and umifenovir (in patient therapies) were also recently recorded as having anti-SARS-CoV-2 effects. Since the recoveries/deaths ratio in the last weeks significantly increased, especially in China, it is clear that the experi- mental antiviral therapy, together with the availability of intensive care unit beds in hospitals and rigorous government control measures, all play an important role in dealing with this vi- rus. This also stresses the urgent need for the scientific community to devote its efforts to the development of other more specific antiviral strategies.

Keywords: SARS-CoV-2, Coronavirus, COVID-19, antiviral drugs, hydroxychloroquine, remdesivir, favipiravir, lopinavir, ritonavir.

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(E-pub Ahead of Print)
DOI: 10.2174/0929867327666200416131117

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