Background: Emerging viral zoonotic diseases are one of the major obstacles to secure the
‘‘One Health” concept under the current scenario. Current prophylactic, diagnostic and therapeutic approaches
often associated with certain limitations and thus proved to be insufficient for customizing rapid
and efficient combating strategy against the highly transmissible pathogenic infectious agents leading to
the disastrous socio-economic outcome. Moreover, most of the viral zoonoses originate from the wildlife
and poor knowledge about the global virome database renders it difficult to predict future outbreaks.
Thus, alternative management strategy in terms of improved prophylactic vaccines and their delivery
systems; rapid and efficient diagnostics and effective targeted therapeutics are the need of the hour.
Methods: Structured literature search has been performed with specific keywords in bibliographic databases
for the accumulation of information regarding current nanomedicine interventions along with standard
books for basic virology inputs.
Results: Multi-arrayed applications of nanomedicine have proved to be an effective alternative in all the
aspects regarding the prevention, diagnosis, and control of zoonotic viral diseases. The current review is
focused to outline the applications of nanomaterials as anti-viral vaccines or vaccine/drug delivery systems,
diagnostics and directly acting therapeutic agents in combating the important zoonotic viral diseases
in the recent scenario along with their potential benefits, challenges and prospects to design successful
Conclusion: This review provides significant introspection towards the multi-arrayed applications of
nanomedicine to combat several important zoonotic viral diseases.