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ISSN (Online): 2212-4039

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Review Article

Fast Dissolving/Disintegrating Dosage Forms of Natural Active Compounds and Alternative Medicines

Author(s): Anupama Singh, Vandana Kharb and Vikas Anand Saharan *

Volume 14, Issue 1, 2020

Page: [21 - 39] Pages: 19

DOI: 10.2174/1872211314666200324174703

Price: $65

Abstract

Fast Dissolving/Disintegrating Dosage Forms (FDDFs) are a group of dosage forms which dissolve or disintegrate quickly, leading to fast distribution of active ingredients at the site of administration; thereby providing ease of oral ingestion of solid unit dosage forms and have the potential to enhance transmucosal absorption. With time, the use of FDDFs in alternative systems has significantly increased. Homeopathic systems and traditional Chinese medicine have embraced FDDFs for the delivery of active compounds. Most of the patents in this area are from China or by the Chinese innovators. In Europe and US, FDDFs have been extensively studied for the delivery of natural active compounds. It was fascinating to know that some new dosage forms and new routes of delivering active compounds are also making their way to the family of FDDFs. The dose of active compound, size of dosage forms, standardization of extracts, polyherbal mixtures, stability of active compounds, safety, efficacy and pharmacokinetics are challenging issues for developing FDDF herbal formulations or phytopharmaceuticals.

Keywords: Orodispersible, orally disintegrating, tablets, films, pellets, fibers, mats, Ayurvedic, herbal, homeopathy, traditional Chinese medicine, nutraceuticals, phytopharmaceuticals, extract.

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[1]
Saharan VA, Singh A, Kharb V. Fast Dissolving/Disintegrating Dosage Forms: Introducing through Development, Market, Pharmacopoeial and Regulatory Status. In: Current advances in drug delivery through fast dissolving/disintegrating dosage forms. Saharan VA (ed). UAE: Bentham Science Publishers 2017; pp. 3-18.
[2]
Devi VK, Jain N, Valli KS. Importance of novel drug delivery systems in herbal medicines. Pharmacogn Rev 2010; 4(7): 27-31.
[http://dx.doi.org/10.4103/0973-7847.65322] [PMID: 22228938]
[3]
Saharan VA. Current advances in drug delivery through fast dissolving/disintegrating dosage forms. Bentham Science Publishers 2017.
[http://dx.doi.org/10.2174/97816810845961170101]
[4]
Sharma V, Gupta M, Chauhan DN, Chauhan NS, Goyal RK, Shah K. Novel Drug Delivery Systems for Phytoconstituents: Current and Future Prospects. In: Novel Drug Delivery Systems for Phytoconstituents. Gupta M, Chauhan DN, Sharma V, Chauhan NS. (eds). CRC Press 2020; pp. 3-8.
[5]
Kopelman SH, Jin P, Augsburger LL. Botanicals and Their Formulation into Oral Solid Dosage Forms. In: In: Pharmaceutical Dosage Forms: Tablets, Volume 2: Rational Design and Formulation, 3rd edition, Augsburger LL, Hoag SW (eds). Informa Healthcare, 2008; pp. 333-360.
[http://dx.doi.org/10.3109/9781420020298-12]
[6]
FDA. Guidance for Industry. Orally Disintegrating Tablets US Department of Health and Human Services Food and Drug Administration Center for Drug Evaluation and Research (CDER) [Internet] 2008. https://www.fda.gov/media/70877/download
[7]
Bonati A. Formulation of plant extracts into dosage forms The Medicinal Plant Industry. CRC Press 1991; pp. 107-14.
[8]
da Silva RML, Couto AEG, Bresolin TM. Medicinal plants and pharmaceutical technology. Plant Bioact Drug Discov Princ Pract Perspect 2012; 17: 359-93.
[9]
Zheng X, Wu F, Hong Y, Shen L, Lin X, Feng Y. Developments in taste-masking techniques for traditional Chinese medicines. Pharmaceutics 2018; 10(3): 157.
[http://dx.doi.org/10.3390/pharmaceutics10030157] [PMID: 30213035]
[10]
Borges JG, De Carvalho RA. Orally disintegrating films containing propolis: Properties and release profile. J Pharm Sci 2015; 104(4): 1431-9.
[http://dx.doi.org/10.1002/jps.24355] [PMID: 25631489]
[11]
Borges JG, Silva AG, Cervi-Bitencourt CM, Vanin FM, Carvalho RA. Lecithin, gelatin and hydrolyzed collagen orally disintegrating films: functional properties. Int J Biol Macromol 2016; 86: 907-16.
[http://dx.doi.org/10.1016/j.ijbiomac.2016.01.089] [PMID: 26826291]
[12]
Borges JG, Tagliamento M, Silva AG. Sobral PJ do A, Carvalho RA de. Development and characterization of orally-disintegrating films for propolis delivery. Food Sci Technol 2013; 33: 28-33.
[http://dx.doi.org/10.1590/S0101-20612013000500005]
[13]
Adomavičiūtė E, Stanys S, Žilius M, Juškaitė V, Pavilonis A, Briedis V. Formation and biopharmaceutical characterization of electrospun PVP mats with propolis and silver nanoparticles for fast releasing wound dressing. BioMed Res Int 2016; 2016 4648287
[http://dx.doi.org/10.1155/2016/4648287] [PMID: 26981531]
[14]
Hirave RV, Kondawar MS. Development & evaluation of herbal fast dissolving tablet of Capparis divaricata Lam. Int J Adv Pharm 6(1): 24-30
[15]
Daud AS, Sapkal NP, Bonde MN. Development of Zingiber officinale in oral dissolving films: Effect of polymers on in vitro, in vivo parameters and clinical efficacy. Asian J Pharm 2014; 5(3): 183-9.
[16]
Tiwari OP. Formulation and development of fast dissolving tablet of methanolic extract of some traditionally used medicinal plants for arthritis. Int J Pharm Biol Arch Int J Pharm Biol Arch 2017; 8(3): 28-32 [cited 2019 Sep 2] Available from: https://www.ijpba.info/ijpba/index.php/ijpba/article/view/1528
[17]
Puri D, Bhandari A, Gaur PK, et al. Formulation of herbal fast disintegrating tablets and its ex-vivo study for anti-histaminic activity in guinea pig ileum. Curr Clin Pharmacol 2018; 13(2): 128-35.
[http://dx.doi.org/10.2174/1574884713666180309153942] [PMID: 29521214]
[18]
Tedesco MP, Monaco-Lourenço CA, Carvalho RA. Characterization of oral disintegrating film of peanut skin extract-Potential route for buccal delivery of phenolic compounds. Int J Biol Macromol 2017; 97: 418-25.
[http://dx.doi.org/10.1016/j.ijbiomac.2017.01.044] [PMID: 28093333]
[19]
Kucinskaite A, Sawicki W, Briedis V, Sznitowska M. Fast disintegrating tablets containing Rhodiola rosea L. extract. Acta Pol Pharm 2007; 64(1): 63-7.
[PMID: 17665852]
[20]
Nam S, Lee J-J, Lee SY, Jeong JY, Kang W-S, Cho H-J. Angelica gigas Nakai extract-loaded fast-dissolving nanofiber based on poly(vinyl alcohol) and Soluplus for oral cancer therapy. Int J Pharm 2017; 526(1-2): 225-34.
[http://dx.doi.org/10.1016/j.ijpharm.2017.05.004] [PMID: 28478278]
[21]
Zabaiou N, Fouache A, Trousson A, et al. Biological properties of propolis extracts: Something new from an ancient product. Chem Phys Lipids 2017; 207(Pt B): 214-22.. 2017.
[22]
Tanaka H, Iwao Y, Izumikawa M, et al. Preparation of orally disintegrating tablets containing powdered tea leaves with enriched levels of bioactive compounds by means of microwave irradiation technique. Chem Pharm Bull (Tokyo) 2016; 64(9): 1288-97.
[http://dx.doi.org/10.1248/cpb.c16-00224] [PMID: 27581633]
[23]
Hirata A, Funato H, Nakai M, et al. Ginger orally disintegrating tablets to improve swallowing in older people. Biol Pharm Bull 2016; 39(7): 1107-11.
[http://dx.doi.org/10.1248/bpb.b15-01045] [PMID: 27374286]
[24]
Abe N, Hirata A, Funato H, et al. Swallowing function improvement effect of ginger (Zingiber officinale). Food Sci Technol Res 2015; 21(5): 705-14.
[http://dx.doi.org/10.3136/fstr.21.705]
[25]
Krekeler A. Orodispersible film. EP3169306A1, . 2015.
[26]
Heinemann RJB, Carvalho RA, Favaro-Trindade CS. Orally disintegrating film (ODF) for delivery of probiotics in the oral cavity — Development of a novel product for oral health. 2013. [cited 2019 Sep 2]; Available from: . https://pubag.nal.usda.gov/catalog/599960
[27]
Hoffmann A, Daniels R. Ultra-fast disintegrating ODTs comprising viable probiotic bacteria and HPMC as a mucoadhesive. Eur J Pharm Biopharm 2019; 139: 240-5.
[http://dx.doi.org/10.1016/j.ejpb.2019.03.022] [PMID: 30946916]
[28]
Garcia VA dos S. Borges JGM, Mazalli MR, et al. Gelatin and pregelatinized starch orally disintegrating films: Properties and stability of vitamin C. J Appl Polym Sci 2017; 134(20): 44841. Available from:. https://onlinelibrary.wiley.com/doi/abs/10.1002/app.44841
[29]
Garcia VA dos S. Gelatin/starch orally disintegrating films as a promising system for vitamin C delivery. Food Hydrocoll 2018; 79: 127-35.
[http://dx.doi.org/10.1016/j.foodhyd.2017.12.027]
[30]
Olah I, Lasher J, Regdon G, Pintye-Hodi K, Baki G, Sovany T. Evaluating superdisintegrants for their performance in orally disintegrating tablets containing lysozyme enzyme. J Drug Deliv Sci Technol 2019; 49: 396-404.
[http://dx.doi.org/10.1016/j.jddst.2018.12.012]
[31]
Agiba AM, Abdel-Hamid S, Nasr M, Geneidi AS. Geriatric-oriented high dose nutraceutical ODTs: Formulation and physicomechanical characterization. Curr Drug Deliv 2018; 15(2): 267-77.
[http://dx.doi.org/10.2174/1567201814666170320143824] [PMID: 28322163]
[32]
Ali MA, Yusof YA, Chin NL, Ibrahim MN, Muneer S. Development and standardization of Moringa oleifera leaves as a natural dietary supplement. J Diet Suppl 2019; 16(1): 66-85.
[http://dx.doi.org/10.1080/19390211.2018.1429517] [PMID: 29469600]
[33]
Tedesco MP. Filmes de desintegração oral produzidos por tape casting - perspectiva para veiculação de compostos ativos extraídos do resíduo industrial de acerola. Internet; Universidade de São Paulo 2018.[Available from:]. http://www.teses.usp.br/teses/disponiveis/74/74132/tde-23102018-091835/
[34]
Khobragde D, Kotha A, Ravalika K, Gupta R, Kumar PV. Oro-Dispersible Tablets of Ayurvedic Powder for improving taste, compliance, Ease and accuracy of administration. Int J Adv Sci Res 2016; 2(6): 131-3.
[http://dx.doi.org/10.7439/ijasr.v2i6.3458]
[35]
Kagalkar AA, Nanjwade B, Bagli RS. Development and evaluation of herbal fast dissolving tablets of Tectona grandis Linn. Int J Pharma Res Rev 2014; 3: 6-14.
[36]
Kagalkar AA, Nitave SA. Development & evaluation of herbal fast dissolving tablet of Bauhenia veriagata Linn. Int J MediPharm Res 2015; 1(2): 169-73.
[37]
Fatma R, Nandi P, Gupta A. Novel approach for preparation fast dissolving tablets of Gymnema sylvestre. World J Pharm Pharm Sci 2014; 3(8): 622-44.
[38]
Akula NP, Sekhar BC, Sharma J. Rapid dispersible tablets of some ayurvedic churnas. J Chem Pharm Sci 2012; 5(2): 42-5.
[39]
Achhra CV, Pawar HA. Development and evaluation of sucrose free herbal orally disintegrating tablets of ginger. J Bioanal Biomed 2017; 9: 288-93.
[40]
Kagalkar AA, Nitave S. Development & evaluation of herbal fast dissolving tablet of Tectona grandis Linn & Bauhenia veriagata Linn. mixture. Int J Pharm Tech Res 2014; 6: 1600-7.
[41]
New Poly-Herbal Asthma Medicine to Fight Asthma; COPD, and Other Lung Problems Press Release for Res-Q [Internet] Ayurvedic Medicine Blog 2008 Sep; 29 Available from:. https://asokalife.wordpress.com/press-release-for-res-q/
[42]
Mukherjee P. JU laboratory brings out wonder drug for asthma patients Kolkata News - Times of India [2008 Sep; 29 Available from: . https://timesofindia.indiatimes.com/city/kolkata/JU-laboratory-brings-out-wonder-drug-for-asthma-patients/articleshow/3656555cms].
[43]
Kale VV, Wattamwar AB, Daud AS. Rapid dissolvable oral film for delivering herbal extract/s with or without other pharmaceutically active agents. WO2010146601A1. 2010.
[44]
Joshi HN. Combination drug therapy using orally dissolving film or orally disintegrating tablet dosage forms to treat dry mouth ailments. US20090263467A1,. 2008.
[45]
Zhang W, Wang Y, Gao X, et al. Optimization of Jiawei Qing’e oral fast disintegrating tablets based on response surface-central composite design. Chin Herb Med 2013; 5(2): 138-44.
[46]
Ye B, Liu Z, Ji Y, Bao R. Preparation and evaluation quality of Folium ginkgo orally disintegrating tablets 2003.15(4): 326-9..
[47]
Xie Y, Wang X. Preparation of Ciwujianaoling orally disintegrating tablets. Zhongguo Yiyuan Yaoxue Zazhi 2007; 27(4): 496.
[48]
Wang Z, Wei L, Chen T. Formulation optimization of panax notoginsenoside orally fast disintegration tablets. Zhongguo Zhong Yao Za Zhi Zhongguo Zhongyao Zazhi China J Chin Mater Medica 2008; 33(14): 1676-80.
[49]
Xie L, Chen Z, Yang H, Jia M, Zeng W. Study on preparation of orally disintegrating tablets of Rhizoma Menispermi. Zhongguo Yiyuan Yaoxue Zazhi 2008; 22.
[50]
Zhang L, Yanli YU, Xiaoming LI. Preparation and quality control of breviscapine orally disintegrating tablet. China Pharm 2005; p. 15.
[51]
Zhang L, Cui M, Yin R, Zhu S, Chen L, Kong Y. The research of Traditional Chinese Medicine orally disintegrating tablets. Pharm Clin Chin Mater Medica 2012; 3(5): 53-6.
[52]
Jin Y-L, Feng S-H, Zhang T-J, Bai M-X. Research Progress on orally disintegrating tablets of Chinese materia medica. Chin Tradit Herbal Drugs 2018; 49: 5456-62.
[53]
Li Q, Guo L, Zhang J, Chai J. Study on quality standard for fufang tianma gouteng orally disintegrating tablets. Zhongguo Zhongyiyao Xinxi Zazhi 2014; (2): 85-7.
[54]
Jiang H, Wang J. Yunnan Manyleaf paris Rhizome extract ora disintegration tablet and its preparing process. CN1682966A . 2005.
[55]
Jiang H, Wang J. The oral disintegratable tablet of ginkgo leaves. WO2005063267A1. 2004.
[56]
Gu M, Su J. Composition containing lutein/lutein ester and applications thereof. WO2018019048A1, . 2016.
[57]
Wang J. Orally disintegrating tablet of pseuto-ginseng total saponins and its preparation. CN1250228C. 2004.
[58]
Zhang Q. Orally disintegrating tablet of “Xintongning” and its preparation. CN1271995C. 2004.
[59]
Zhang Q. Wild chrysanthemum oral disintegration tablet and its preparing method. CN1277550C, . 2004.
[60]
Lu J, Qian G. Stellera chamaejasm component orally disintegrating tablet. CN103877267A,. 2014.
[61]
Yang Y, Jiang A. Corydalis decumbentis orally disintegrating tablets. CN101209288B, . 2006.
[62]
Lee S-H. Gangwon-do. Orally disintegrating tablet containing chinese herbal medicine for suppressing appetite and preparation method therefor. WO2015050283A1,.. 2013.
[63]
Zhang S, Wang H, Zhao L, Wu B. Orally disintegrating tablets for treating functional dyspepsia. CN102302701A. 2011.
[64]
Zhao Y, Xiao X, Wang Q, Yan D. Orally rapid disintegrating tablet of isatidis root extract and preparation method thereof. CN102228491A, . 2011.
[65]
Yekun Y, Xuemei L, Enming M, Yongqin G, Mingming M, Yuling W, et al. Orally-disintegrating-tablet-type smokeless tobacco product containing tobacco ultra-micro powder and preparation method thereof. CN103549646A,. 2013.
[66]
Kexue H. Qingkailing and bupleurum orally disintegrating tablets for animals and preparation method thereof. CN102872234A. 2012.
[67]
Zhu D, Cheng D. Traditional Chinese medicinal composition for treating dental ulcer, orally disintegrating tablet of traditional Chinese medicinal composition, and applications of traditional Chinese medicinal composition and orally disintegrating tablet. CN106265941A. 2015.
[68]
Zhang Q. Shenmai oral disintegration tablet and its preparing method. CN1899506A, . 2005.
[69]
Lang Y. Traditional Chinese medicine and western medicine orally disintegrating tablet for treating senile emphysema and preparation method thereof. CN106038855A. 2016.
[70]
Ding X. Veterinary Chinese and western medicinal compound orally-disintegrating micropowder tablet and preparation method thereof. CN104666401A,. 2015.
[71]
Liu Y. Xinkangtai orally disintegrating tablet and preparation method thereof. CN102526184A. 2012.
[72]
Monton C, Saingam W, Suksaeree J, Sakunpak A, Kraisintu K. Preformulation and physical properties study of fast disintegrating tablets from Thai traditional formula. Int J Pharm Pharm Sci 2014; 6: 431-4.
[73]
Choi H-K, Kang K-W, Chun M-K, Kim S-C, Kim Y-G. Composition for fast disintegrating tablet containing herbal extract and its preparation method. WO2008136636A1. 2008.
[74]
Matsumoto N, Ishikawa NK. Crude drug-containing tablet and method for producing herbal medicine-bearing particles for herbal medicine-containing tablet. JP5530716B2, 2009..
[75]
Reda H-S, Yves L, Tewfik H-S. Transmucosal composition containing anthocyanins for alleviating a visual discomfort. US20130115174A1, 2011..
[76]
Khan MA, Ameen S, Zia A, et al. Extraction, formulation and evaluation of fast dissolving oral films of nicotine for smoking cessation 2018.2(1): 1..
[77]
Cilurzo F, Cupone IE, Minghetti P, et al. Nicotine fast dissolving films made of maltodextrins: A feasibility study. AAPS PharmSciTech 2010; 11(4): 1511-7.
[http://dx.doi.org/10.1208/s12249-010-9525-6] [PMID: 20936440]
[78]
Shen C, Shen B, Xu H, et al. Formulation and optimization of a novel oral fast dissolving film containing drug nanoparticles by Box-Behnken design-response surface methodology. Drug Dev Ind Pharm 2014; 40(5): 649-56.
[http://dx.doi.org/10.3109/03639045.2014.884116] [PMID: 24506458]
[79]
Lal M, Lai M, Ugaonkar S, et al. Development of a vaginal fast-dissolving insert combining griffithsin and carrageenan for potential use against sexually transmitted infections. J Pharm Sci 2018; 107(10): 2601-10.
[http://dx.doi.org/10.1016/j.xphs.2018.06.002] [PMID: 29902477]
[80]
Derby N, Lal M, Aravantinou M, et al. Griffithsin carrageenan fast dissolving inserts prevent SHIV HSV-2 and HPV infections in vivo. Nat Commun 2018; 9(1): 3881.
[http://dx.doi.org/10.1038/s41467-018-06349-0] [PMID: 30250170]
[81]
Li X-Y, Li Y-C, Yu D-G, Liao Y-Z, Wang X. Fast disintegrating quercetin-loaded drug delivery systems fabricated using coaxial electrospinning. Int J Mol Sci 2013; 14(11): 21647-59.
[http://dx.doi.org/10.3390/ijms141121647] [PMID: 24185912]
[82]
Li C, Yu D-G, Williams GR, Wang Z-H. Fast-dissolving core-shell composite microparticles of quercetin fabricated using a coaxial electrospray process. PLoS One 2014; 9(3) e92106
[http://dx.doi.org/10.1371/journal.pone.0092106] [PMID: 24643072]
[83]
Zhang L, Tan QY, Cheng XG, Wang H, Hu NN, Zhang JQ. Preparation and quality control of pyridostigmine bromide orally disintegrating tablet. Sichuan Da Xue Xue Bao Yi Xue Ban 2012; 43(3): 458-461, 477.
[PMID: 22812258]
[84]
Zhang L. The Research on Preparation of Pyridostigmine Bromide Orally Disintegrating Tablets - Master’s thesis - Dissertation: Chongqing Medical University [Internet] 2011 Oct; 7. https://www.dissertationtopic.net/doc/448583
[85]
Nam S, Lee SY, Cho H-J. Phloretin-loaded fast dissolving nanofibers for the locoregional therapy of oral squamous cell carcinoma. J Colloid Interface Sci 2017; 508: 112-20.
[http://dx.doi.org/10.1016/j.jcis.2017.08.030] [PMID: 28822860]
[86]
Apolinário RS, Chaves MDGAM, Gonçalves HRM, et al. Compounded orodispersible films with natural ingredients for halitosis: A clinical experience. Int J Pharm Compd 2018; 22(6): 512-5.
[PMID: 30384352]
[87]
Eliphaz M. Formulation of a natural intraoral dispersible film (IDF)for intraoral delivery of various natural drugs using edible rice paper film as the carrier vehicle [Internet] [Thesis] 2016 Oct; 7 Available from: . http://wiredspace.wits.ac.za/handle/10539/23303
[88]
Yu F, Xu X, Tang X, Yang Z. Preparation and quality evaluation of resveratrol orally disintegrating tablets Chin Tradit Herb Drug 47(2): 227-32..
[89]
Shaik SS, Kameswara RS, Swati S, Vani T. Formulation and evaluation of herbal fast dissolving buccal film containing curcumin. World J Pharm Pharm Sci 2018; 7(4): 1617-35.
[90]
Speer I, Preis M, Breitkreutz J. Dissolution testing of oral film preparations: Experimental comparison of compendial and non-compendial methods. Int J Pharm 2019; 561: 124-34.
[http://dx.doi.org/10.1016/j.ijpharm.2019.02.042] [PMID: 30826424]
[91]
Krampe R, Sieber D, Pein-Hackelbusch M, Breitkreutz J. A new biorelevant dissolution method for orodispersible films. Eur J Pharm Biopharm 2016; 98: 20-5.
[http://dx.doi.org/10.1016/j.ejpb.2015.10.012] [PMID: 26515261]

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