Background: Nowadays microbial infections are considered the most important causes of morbidity and mortality. Various microorganisms including biofilm-forming bacteria reported playing a crucial role in such public health concerns. On the other hand, the inefficacy of conventional antimicrobial agents may due to various reasons including drug resistance creates a need for the development of effective drug molecules. In this context, nanoparticles can be promisingly used in the management of all such concerns.
Objective: The study aimed to evaluate antibacterial and biofilm removal efficacy of various metal nanoparticles against biofilm-forming bacteria.
Methods: Various metal nanoparticles including silver (AgNPs), copper (CuNPs) and zinc oxide (ZnONPs) were synthesized from plant leaf extracts of Punica granatum, Citrus medica, and Annona squamosa, respectively.
Results: Thus synthesized nanoparticles were evaluated for their antibacterial and biofilm removal efficacies against Enterococcus gallinarum, Staphylococcus haemolyticus, Enterobacter aerogenes, and Salmonella enterica serovar Typhi to propose a promising approach towards management of such pathogens. In vitro antibacterial study demonstrated that AgNPs showed the maximum efficacy against all the test bacteria followed by CuNPs and ZnONPs.