A Brief Review on the Development of Novel Potentially Active Azetidin-2-ones Against Cancer

Author(s): Ligia S. da Silveira Pinto, Thatyana R. Alves Vasconcelos*, Claudia Regina B. Gomes, Marcus Vinícius N. de Souza.

Journal Name: Current Organic Chemistry

Volume 24 , Issue 5 , 2020

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Graphical Abstract:


Azetidin-2-ones (β-lactams) and its derivatives are an important group of heterocyclic compounds that exhibit a wide range of pharmacological properties such as antibacterial, anticancer, anti-diabetic, anti-inflammatory and anticonvulsant. Efforts have been made over the years to develop novel congeners with superior biological activities and minimal potential for undesirable side effects. The present review aimed to highlight some recent discoveries (2013-2019) on the development of novel azetidin-2-one-based compounds as potential anticancer agents.

Keywords: Azetidin-2-ones, β-lactams, biological activity, cancer, drugs, heterocycles.

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Article Details

Year: 2020
Page: [473 - 486]
Pages: 14
DOI: 10.2174/1385272824666200303115444
Price: $58

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