Azetidin-2-ones (β-lactams) and its derivatives are an important group of heterocyclic
compounds that exhibit a wide range of pharmacological properties such as antibacterial,
anticancer, anti-diabetic, anti-inflammatory and anticonvulsant. Efforts have
been made over the years to develop novel congeners with superior biological activities
and minimal potential for undesirable side effects. The present review aimed to highlight
some recent discoveries (2013-2019) on the development of novel azetidin-2-one-based
compounds as potential anticancer agents.
Keywords: Azetidin-2-ones, β-lactams, biological activity, cancer, drugs, heterocycles.
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