Bis(indolyl)methane skeleton is the main building block of many naturally occurring bioactive compounds. Bis(indolyl)methanes are found to possess a wide range of pharmaceuitical efficacies. These important scaffolds are being used as anti-cancer, anti-oxidant, anti-bacterial, anti-inflammatory, anti-proliferative etc agents. In this review we have summarized the latest developments on the synthesis of various bis/tris(indolyl)methane derivatives from the reactions of two equivalents of indoles and one equivalent of aldehydes or indole-3-carbaldehydes under various reaction conditions. More than hundred different catalysts were employed for these transformations which include various metal catalysts, ionic liquids, organocatalysts, surfactants, homogeneous and heterogeneous catalysts etc.
Keywords: Bis(indolyl)methanes, tris(indolyl)methanes, homogeneous catalysts, heterogeneous catalysts, biological activities
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