Cancer is one of the global prominent causes of death and foremost worldwide health concern. Despite unprecedented progress in cancer chemoprevention, vast number of cancers however remain an undefeatable challenge for treatment modalities. Immense therapeutic activities of puerarin contribute to its use in various health disorders. In this review, we explored the potential molecular mechanisms and targets of puerarin proving its potential as a novel anticancer agent, for future cancer therapy and chemoprevention. Several mechanisms account for anticancer activity of puerarin which include downregulation of NF-kB signalling pathway, mTOR signalling pathway, PI3K and BCl-2 proteins and upregulation of miR-16, caspase proteins, c-Jun N terminal kinase and extracellular signal regulated kinase 1/2. These alterations result in inhibition of cancer cells proliferation and /or induction of apoptosis. Understanding molecular mechanisms involved in chemotherapy and chemoprevention could aid in more pronounced exploration of puerarin in effective cancer treatment.
Keywords: Puerarin, isoflavones, polyphenols, neoplasms, chemoprevention, adjuvant
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