Tubulin Proteins in Cancer Resistance: A Review

(E-pub Ahead of Print)

Author(s): Mohammad A. Kamal, Maryam H. Al-Zahrani, Salman Hasan Khan, Mateen Hasan Khan, Hani Awad Al Subhi, Abudukadeer Kuerban, Muhammad Aslam, Fahad A. Al Abassi, Firoz Anwar*.

Journal Name: Current Drug Metabolism

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Cancer cells are altered with cell cycle genes or they are mutated that lead to high rate of proliferation compared to normal cells. Alteration in these genes lead to mitosis dysregulation and becomes the very bases tumour progression and resistance to many drugs. The drugs which act on the cell cycle fails to arrest the process, making a cancer cell non responsive to apoptosis or cell death. Vinca alkaloids and taxanes falls in this category and referred as antimitotic agents. Microtubule proteins plays important role in mitosis during cell division a target site for Vinca alkaloids and taxanes. These proteins are dynamic in nature and are composed of α–β-tubulin heterodimers. β - tubulin specially βΙΙΙ isotype is generally altered in expression within cancerous cells. Initially these drugs were very effective in treatment of cancer but fails to show their desired action after initial chemotherapy. The present review highlights some of the important targets and their mechanism of resistance offered by cancer cells with new promising drugs from natural sources that can give the lead for the development new approach to chemotherapy.

Keywords: Tubulin, Cancer, Proteins, Resistance, Vinca Alkaloids , Taxenes

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1389200221666200226123638
Price: $95