Amidoalkyl-2-naphthol is one of the vital synthetic intermediates which occupy
an imperative position in medicinal chemistry due to its amazing biological, pharmacological
as well as industrial and synthetic applications. Owing to its diverse pharmaceutical
activities, hundreds of scientific literature are available, signifying the efficient synthesis
of this intermediate using various catalysts. Most of these literature methods suffer from
low yield and harsh reaction conditions that further ignited the researcher to explore for
another green catalyst and fresh methodologies. This review summarizes the last five
years progress in the catalytic synthesis of 1-amidoalkyl-2-naphthols using various heterogenous,
homogenous and nanocatalysts along with their mechanism of action. Various
advantages like green synthesis, atom economy, clean reaction profile and catalyst recovery
are discussed which facilitate the scientist to probe and stimulate the study on this scaffold. In the end, the
catalysts and reactions condition are organized into the tables for swift at a glance understanding of different
catalysts used with their yield and time taken for the synthesis.
Keywords: Amidoalkyl-naphthol, green catalyst, heterogenous catalyst, homogenous catalyst, nanocatalyst, multicomponent reactions.
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