Current Progress in the Multicomponent Catalytic Synthesis of Amidoalkyl- Naphthols: An Update

(E-pub Ahead of Print)

Author(s): Rajesh K. Singh*, Ashima Dhiman, Shallu Chaudhary, Deo Nandan Prasad, Sahil Kumar.

Journal Name: Current Organic Chemistry

Become EABM
Become Reviewer


Amidoalkyl-2-naphthol is one of the vital synthetic intermediates which occupy an imperative position in medicinal chemistry due to its amazing biological, pharmacological as well as industrial and synthetic applications. Owing to its diverse pharmaceutical activities, hundreds of scientific literature are available which signifying the efficient synthesis of this intermediate. Most of these methods suffer from low yield and harsh reaction conditions that further ignited the researcher to explore for another green catalyst and fresh methodologies. This review summarizes the last five years progress in the synthesis of 1-amidoalkyl-2-naphthols using various heterogenous, homogenous and nanocatalysts along with their mechanism of action. Various advantages like green synthesis, atom economy, cleaner reaction profile and catalyst recovery are discussed which help the scientist to probe and stimulate the study on this scaffold. In the end, the catalysts and reactions condition are organized into the tables for swift at a glance understanding of different catalysts used with their yield and time taken for the synthesis.

Keywords: Amidoalkyl-naphthol, Green catalyst, Heterogenous catalyst, Homogenous catalyst, Nanocatalyst, Multicomponent reactions

Rights & PermissionsPrintExport Cite as

Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1385272822666200217100344
Price: $95

Article Metrics

PDF: 1