Tetrazoloquinolines: Synthesis, Reactions, and Applications

Author(s): Rizk E. Khidre*, Tahah A. Ameen, Mounir A. I. Salem.

Journal Name: Current Organic Chemistry

Volume 24 , Issue 4 , 2020

Become EABM
Become Reviewer


This review summarizes the synthesis, reactions, and biological activities of tetrazolo[1,5-a]quinoline derivatives. These derivatives were synthesized by several methods such as i) from the reaction of 2-chloroquinoline with sodium azide ii) from diazotization 2-hydrazinylquinoline derivatives, and iii) from intramolecular cyclocondensation of 2-azidoarylidenes. Also, the chemical reactions and pharmacological activities of some tetrazoloquinolines such as tetrazolo[1,5-a]quinoline-4-carbaldehyde, 5- chlorotetrazolo[1,5-a]quinoline, 4-(chloromethyl)tetrazolo[1,5-a]quinoline, tetrazolo[1,5- a]quinoline-4-carboxylic acid, and 5-azidotetrazolo[1,5-a]quinoline were discussed.

Keywords: Quinoline, tetrazoloquinoline, pyrimidine, pyrazole, heterocycles, pharmacological activities.

Rights & PermissionsPrintExport Cite as

Article Details

Year: 2020
Page: [439 - 464]
Pages: 26
DOI: 10.2174/1385272824666200217095341
Price: $95

Article Metrics

PDF: 1