Talin is an intracellular cytoskeletal protein and one of the major components of the focal adhesion complex.
It mainly acts as an interlink between transmembrane integrin receptors and cytosolic F-actin. Apart from integrins
and actin, it also interacts with various other proteins in the adhesion complex to regulate their functional
dynamics. Talin undergoes a variety of post-translational modifications and they are implicated in the control of cell
motility. There are two talin isoforms (talin1 and talin2) in mammals and they are encoded by TLN1 and TLN2
genes, respectively. Recent studies showed that both the isoforms have some mechanistic dissimilarities in terms of
their interaction with membrane-bound integrins. Among the two isoforms, talin1 was well studied, and most of the
information available till now comes from talin1. The present review is aimed to provide an updated overview on the
cellular significance of talin in normal and cancerous cells.
Keywords: Cancer, extra cellular matrix, focal adhesions, post translational modifications, talin, knock out.
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