Cancer commands the second highest global mortality rate and causes severe public health problems.
Recent advances have been made in cancer therapy but the incidence of the disease remains high. Research on
more efficient treatment methods with reduced side effects is necessary. Historically, edible plants have been
used as traditional medicines for various diseases. These demonstrate the potential of natural products as sources
of bioactive compounds for anticancer treatment. Anticancer properties of phytochemicals are attributed to
bioactive compounds in plant extracts that suppress cancer cell proliferation and growth by inducing both cell
cycle arrest and apoptosis. This review presents a summary of the molecular identification of phytochemicals
with anticancer properties and details their action mechanisms and molecular targets. Moreover, the effects of
the natural product on both immunomodulatory and anticancer properties are provided.
Keywords: Anticancer, natural product, apoptosis, cell cycle, immunomodulatory, receptor tyrosine kinase.
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