The pluripotent state of stem cells depends on the complicated network orchestrated by
thousands of factors and genes. Long noncoding RNAs (lncRNAs) are a class of RNA longer than 200
nt without a protein-coding function. Single-cell sequencing studies have identified hundreds of
lncRNAs with dynamic changes in somatic cell reprogramming. Accumulating evidence suggests that
they participate in the initiation of reprogramming, maintenance of pluripotency, and developmental
processes by cis and/or trans mechanisms. In particular, they may interact with proteins, RNAs, and
chromatin modifier complexes to form an intricate pluripotency-associated network. In this review, we
focus on recent progress in approaches to profiling functional lncRNAs in somatic cell reprogramming
and cell differentiation.
Keywords: Pluripotency, stem cells, long noncoding RNA, reprogramming, epigenetics, RNA sequencing.
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