Therapeutic peptides (TPs) are biological macromolecules which can act as neurotransmitters,
hormones, ion channel ligands and growth factors. Undoubtedly, TPs are crucial in modern medicine.
But low bio-stability and some special adverse reactions reduce their places to the application.
With the development of nanotechnology, nanoparticles (NPs) in pharmaceutical science gained much
attention. They can encapsulate the TPs into their membrane or shell. Therefore, they can protect the
TPs against degradation and then increase the bioavailability, which was thought to be the biggest
advantage of them. Additionally, targeting was also studied to improve the effect of TPs. However,
there were some drawbacks of nano TPs like low loading efficiency and difficulty to manufacture.
Nowadays, lots of studies focused on improving effect of TPs by preparing nanoparticles. In this review,
we presented a brief analysis of peptide-combined nanoparticles. Their advantages and disadvantages
were listed in terms of mechanism. And several examples of applications were summarized.