Role of Nuclear Factor Kappa B (NF-κB) Signalling in Neurodegenerative Diseases: An Mechanistic Approach

(E-pub Ahead of Print)

Author(s): Shareen Singh*, Thakur Gurjeet Singh.

Journal Name: Current Neuropharmacology

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Abstract:

A transcriptional regulatory nuclear factor kappa B (NF-κB) protein is a modulator of cellular biological activity via binding to a promoter region in the nucleus and transcribing various protein genes. The recent research implicated the intensive role of nuclear factor kappa B (NF-κB) in diseases like autoimmune disorder, inflammatory, cardiovascular and neurodegenerative diseases. Therefore, targeting the nuclear factor kappa B (NF-κB) protein offers a new opportunity as therapeutic approach. Activation of IκB kinase/NF-κB signalling pathway leads to development of various pathological conditions in human being, such as neurodegenerative, inflammatory disorders, autoimmune diseases and cancer. Therefore, the transcriptional activity of IκB kinase/NF-κB is strongly regulated at various cascade pathways. The nuclear factor NF-kB pathway plays a major role in expression of pro-inflammatory genes including cytokines, chemokines, and adhesion molecules. In response to the diverse stimuli, the cytosolic sequestered NF-κB in an inactivated form by binding with an inhibitor molecule protein (IkB) gets phosphorylated and translocated into the nucleus further transcribing various genes necessary for modifying various cellular functions. The various researches confirmed the role of different family member proteins of NF-κB implicated in expressing various genes products and mediating various cellular cascades. MicroRNAs, as regulators of NF- κB microRNAs play important roles in the regulation of the inflammatory process. Therefore, the inhibitor of NF-κB and its family members plays a novel therapeutic target in preventing the various diseases. Regulation of NF- κB signalling pathway may be a safe and effective treatment strategy for various disorders.

Keywords: Transcriptional, Nuclear factor kappa B (NF-κB), MicroRNAs, Pro-inflammatory genes, Neurodegenerative, Inflammatory disorders, Autoimmune diseases

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1570159X18666200207120949
Price: $95